解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00466-4
更新日期:2001-10-25 00:00:00
abstract::The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00460-3
更新日期:2001-10-25 00:00:00
abstract::Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00456-1
更新日期:2001-10-11 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00439-1
更新日期:2001-09-27 00:00:00
abstract::cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00449-4
更新日期:2001-09-27 00:00:00
abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00424-x
更新日期:2001-09-13 00:00:00
abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00410-x
更新日期:2001-09-13 00:00:00
abstract::Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00404-4
更新日期:2001-08-30 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00394-4
更新日期:2001-08-30 00:00:00
abstract::Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(01)00380-4
更新日期:2001-08-16 00:00:00
abstract::Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00384-1
更新日期:2001-08-16 00:00:00
abstract::In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00370-1
更新日期:2001-08-02 00:00:00
abstract::Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. A...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00360-9
更新日期:2001-08-02 00:00:00
abstract::GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00345-2
更新日期:2001-07-19 00:00:00
abstract::Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00318-x
更新日期:2001-06-01 00:00:00
abstract::The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00316-6
更新日期:2001-06-01 00:00:00
abstract::Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-rela...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00294-x
更新日期:2001-05-01 00:00:00
abstract::Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00298-7
更新日期:2001-05-01 00:00:00
abstract::Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00268-9
更新日期:2001-04-01 00:00:00
abstract::From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00278-1
更新日期:2001-04-01 00:00:00
abstract::The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00236-7
更新日期:2001-03-01 00:00:00
abstract::Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00246-x
更新日期:2001-03-01 00:00:00
abstract::Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00213-6
更新日期:2001-02-01 00:00:00
abstract::In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00223-9
更新日期:2001-02-01 00:00:00
abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00179-9
更新日期:2001-01-01 00:00:00
abstract::Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00189-1
更新日期:2001-01-01 00:00:00
abstract::Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(01)00199-4
更新日期:2001-01-01 00:00:00
abstract::Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00147-1
更新日期:2000-12-01 00:00:00
abstract::Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00157-4
更新日期:2000-12-01 00:00:00
abstract::Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00167-7
更新日期:2000-12-01 00:00:00
abstract::We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00119-7
更新日期:2000-11-01 00:00:00
abstract::Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00129-x
更新日期:2000-11-01 00:00:00
abstract::Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00092-1
更新日期:2000-10-01 00:00:00
abstract::alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00102-1
更新日期:2000-10-01 00:00:00
abstract::Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00058-1
更新日期:2000-09-01 00:00:00
abstract::X-ray crystallography has made considerable recent progress in providing static structures of ion channels. Here we describe a complementary method-systematic fluorescence scanning-that reveals the structural dynamics of a channel. Local protein motion was measured from changes in the fluorescent intensity of a fluoro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00068-4
更新日期:2000-09-01 00:00:00
abstract::Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00038-6
更新日期:2000-08-01 00:00:00
abstract::Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00008-8
更新日期:2000-07-01 00:00:00
abstract::We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00018-0
更新日期:2000-07-01 00:00:00
abstract::TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-relat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81201-5
更新日期:2000-06-01 00:00:00